Potential Anticancer Activity of Auranofin
نویسندگان
چکیده
منابع مشابه
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53
Auranofin is a gold-containing compound classified by the World Health Organization as a clinically established rheumatoid arthritis therapeutic agent. Through drug screening for novel anticancer therapeutics, we unexpectedly identified auranofin as a potent anticancer agent against a p53-null ovarian carcinoma SKOV3 cell line. However, the molecular mechanism underlying auranofin-mediated anti...
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Auranofin, a gold complex that has been used to treat rheumatoid arthritis in clinics and has documented pharmacokinetic and safety profiles in humans, has recently been investigated for its anticancer activity in leukemia and some solid cancers. However, auranofin's single agent activity in lung cancer is not well characterized. To determine whether auranofin has single agent activity in lung ...
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Cell-penetrating peptides (CPPs) are still an interesting and viable alternative for drug delivery applications. CPPs contain considerably high amounts of positively charged amino acids, imparting them with cationic character. Tumor cells are characterized by an enhanced anionic nature of their membrane surface, a property that could be used by CPPs to target these cells. We recently identified...
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Traditional Medicinal Use Turmeric powder has long been used for medicinal purposes in Asia to treat gastrointestinal upsets, arthritis pain, and "low energy." In traditional Indian Ayurvedic medicine, turmeric has been used as a tonic for the digestive system and the liver; to dispel worms, strengthen the body, and dissolve gallstones; and for menstrual irregularity and arthritis. In old Hindu...
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Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. Materials and Methods: Google scholar, PubMed and Scopus were searched for literatures wh...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2021
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.20-00179-2